Ionis Pharmaceuticals, Inc.(IONS)Stock Performance & ReturnsNASDAQ
Returns, drawdowns and benchmark comparison
Peer Comparison
Relative scale, growth, and profitability vs sector peers
| Ticker | Market Cap | P/E Ratio | Revenue Growth | Net Margin | EPS | ROE | Debt/Equity | Dividend Yield | 52W High | 52W Low |
|---|---|---|---|---|---|---|---|---|---|---|
IONS | 7.34 B | - | -40.70% | -64.66% | -$3.43 | -105.50% | 4.98x | 0.00% | $86.74 | $43.01 |
MRNA | 78.44 B | - | 2.10% | -141.43% | -$7.82 | -39.00% | 0.19x | 0.00% | $208.90 | $22.28 |
NBIX | 14.58 B | 21.16x | 39.50% | 20.91% | $6.78 | 22.09% | 0.13x | 0.00% | $186.12 | $122.14 |
EXEL | 14.48 B | 18.38x | 10.60% | 35.33% | $3.18 | 44.39% | 9.00x | 0.00% | $61.14 | $33.76 |
BBIO | 13.00 B | - | 120.40% | -97.03% | -$3.62 | - | - | 0.00% | $93.42 | $51.85 |
Peer Valuation & Performance Analysis
Peer group analysis for Ionis Pharmaceuticals, Inc. (IONS) compared to its primary competitors (including MRNA, NBIX, EXEL) reveals distinct metrics. IONS trades at a valuation discount relative to its competitors, with a P/E ratio of -12.9x versus the peer average of -1.0x (representing a 1201% discount). This discount might represent an undervalued entry opportunity or reflect specific risk factors the market is discounting. In terms of growth, IONS's revenue growth of -40.7% lags behind the peer average of 43.1%, indicating potential market share losses or slower industry adoption. Additionally, its net margin of -64.7% is below the peer average of -45.6%, suggesting higher operational costs or lower pricing power relative to peers.
Peer Performance Rankings
Ranking comparison across key performance metrics
P/E Ratio (Lower is Better)
Revenue Growth
Net Profit Margin
Financial Rankings Summary
• IONS ranks #0 in P/E ratio, #5 in revenue growth, and #3 in profit margins
• Average ranking: #3 - 📊 Solid financials relative to peer group
• Rankings based on actual financial data from company reports
Historical Trading Data
Price and volume data with customizable timeframes
Showing 15 of 15 trading sessions from the last 15 days
| Date | Open | High | Low | Close | Volume | Daily Change |
|---|---|---|---|---|---|---|
| 2026-10-07 | $43.75 | $44.26 | $43.53 | $44.16 | 2,943,600 | +0.36% |
| 2026-10-06 | $44.19 | $44.67 | $43.17 | $44.00 | 2,192,600 | +1.15% |
| 2026-10-05 | $43.75 | $43.96 | $42.63 | $43.50 | 2,870,600 | -0.09% |
| 2026-10-02 | $44.17 | $44.17 | $43.24 | $43.54 | 2,312,000 | -1.05% |
| 2026-10-01 | $44.63 | $45.95 | $43.96 | $44.00 | 2,030,200 | -1.46% |
| 2026-09-30 | $46.07 | $46.25 | $44.60 | $44.65 | 2,630,200 | -2.70% |
| 2026-09-29 | $45.53 | $46.46 | $45.39 | $45.89 | 3,885,800 | +0.70% |
| 2026-09-28 | $44.56 | $46.95 | $44.06 | $45.57 | 3,742,300 | +2.40% |
| 2026-09-25 | $44.25 | $45.28 | $43.62 | $44.50 | 6,202,100 | +1.57% |
| 2026-09-24 | $43.77 | $44.60 | $43.25 | $43.81 | 6,448,100 | -0.27% |
| 2026-09-23 | $46.23 | $46.41 | $43.01 | $43.93 | 3,535,300 | -3.98% |
| 2026-09-22 | $44.96 | $46.13 | $44.44 | $45.75 | 4,230,800 | +1.89% |
| 2026-09-21 | $44.95 | $45.25 | $44.20 | $44.90 | 4,520,700 | +1.04% |
| 2026-09-18 | $46.75 | $46.75 | $44.27 | $44.44 | 7,369,000 | -4.94% |
| 2026-09-17 | $46.68 | $47.42 | $45.75 | $46.75 | 4,079,600 | +4.26% |
Explore More Analysis for IONS
Additional research, tools, and technical breakdowns
Stock Analyzer Report
Deep-dive automated research and stock rating report.
DCF Fair Value Calculator
Discounted cash flow model and intrinsic value projection.
AI Price Predictions
Multi-scenario price predictions and consensus targets.
Insider Activity Tracker
Track buying/selling behavior of corporate insiders.
Earnings Calendar
Track upcoming and historical corporate earnings reports.
Market Insights & Research
Read the latest analysis articles and expert research.